The cause of generalized trypophobia disorder is not fully
known, but several factors are affecting its development.
Genetics: Some studies suggest that family history plays a
role in whether a person will be prone to trypophobia.
Chemistry in the brain: Trypophobia was associated with abnormal
levels of certain neurotransmitters in the brain. Neurotransmitters are special
chemical "messengers" that help to transfer information between nerve
cells. This could change the way the brain reacts in certain situations, which
can lead to trypophobia.
Environmental factors: Trauma and stressful events (abuse,
death of a loved one, divorce, changing jobs or schools) can lead to trypophobia disorders. Trypophobia is also often exacerbated in periods of stress. Use or
substances such as alcohol, caffeine or nicotine can also worsen trypophobia.
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